effect of folic acid on serum leptin, grehlin concentration, and feed intake in male wistar rats

Authors

mansoor rezaei dept.of community nutrition faculty of nutrition and food technology, shahid beheshti university of medical sciences,tehran, iran

masoumeh sabetkasaei neuroscience research center, dept. pharmacology, shahid beheshti university m.c., tehran, iran

naser kalantari dept. of community nutrition,faculty of nutrition sciences and food technology,shahid beheshti university , m.c.iran

mahdi hedayati endocrine research center, shahid beheshti university , m.c.iran.

abstract

introduction: there is no comprehensive study on the effect of folate on food intake therefore the present study was carried out to determine the effect of folate supplementation on serum concentrations of leptin and grehlin and food intake in male wistar rats. methods: the study was carried out for 42 days during which the animals were weighed weekly their food and water intakes were measured every 48 hours. serum leptin, ghrelin and insulin were measured using elisa. repeated measures and t-test were done to analyze the data. results: the amount of water intake in the case group was significantly (p<0.05) higher that the control group, food intake was also higher in the group receiving folate as compared to the control although it did not reach the significance level. the body weight of the rats receiving the supplement were significantly (p<0.001) higher than the control group. the experimental group had higher serum leptin and lower serum ghrelin levels although not significantly. serum insulin level was significantly higher in the experimental group (p<0.001). a significant correlation was found between water and food intake (r=0.9, p<0.001), and between body weight and the food intake (r=0.6, p<0.001). there was a significant correlation between serum insulin level with food intake (r=0.6, p< 0.001) and body weight (r=0.36, p=0.05). conclusion: daily folate supplementation for a long period increased body growth and food intake in weaning rats. since serum ghrelin level was also higher, it is possible that increased weight was related to the other body tissues, rather than adipose tissue.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effect of Folic Acid on serum Leptin, Grehlin concentration, and feed intake in male Wistar rats

Introduction: There is no comprehensive study on the effect of Folate on food intake therefore the present study was carried out to determine the effect of Folate supplementation on serum concentrations of Leptin and Grehlin and food intake in male Wistar rats. Methods: The study was carried out for 42 days during which the animals were weighed weekly their food and water intakes were measu...

full text

Effect of Folic Acid on serum Leptin, Grehlin concentration, and feed intake in male Wistar rats

Introduction: There is no comprehensive study on the effect of Folate on food intake; therefore the present study was carried out to determine the effect of Folate supplementation on serum concentrations of Leptin and Grehlin and food intake in male Wistar rats. Methods: The study was carried out for 42 days during which the animals were weighed weekly; their food and water intakes were measure...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

the effect of oxytetracycline on serum calcium, phosphorus and magnesium in cattle

نتایج این مطالعه نشان می دهد که مقدار کلسیم (یونیزه و تام)، منیزیم و فسفر به طور معنی داری تغییر پیدا کرد به جزء مقدار کلسیم تام و منیزیم در روش داخل عضلانی که تغییر معنی داری نداشته است. بر اساس نتایج این مطالعه می توان نتیجه گیری کرد که اکسی تتراساکلین بر روی مقادیر سرمی کلسیم و منیزیم تأثیر می گذارد باید مقدار این کاتیون ها در بیماران، در هنگامی که اکسی تتراسایکلین استفاده می شود مورد توجه ق...

15 صفحه اول

Interaction of intracerebroventricular injection of captopril and histamine on water intake in adult male Wistar rats

Several evidences have indicated that many nuclei in the brain have critical role in water intake. Angiotensin II is one of the most important neurotransmitters involved in regulation of fluid homeostasis. In this study, the interaction of i.c.v. injection of captopril and histamine on water intake in adult male water-deprived rats was investigated. Rats were implanted with guide cannula aimed ...

full text

Interaction of intracerebroventricular injection of captopril and histamine on water intake in adult male Wistar rats

Several evidences have indicated that many nuclei in the brain have critical role in water intake. Angiotensin II is one of the most important neurotransmitters involved in regulation of fluid homeostasis. In this study, the interaction of i.c.v. injection of captopril and histamine on water intake in adult male water-deprived rats was investigated. Rats were implanted with guide cannula aimed ...

full text

My Resources

Save resource for easier access later


Journal title:
physiology and pharmacology

جلد ۱۴، شماره ۴، صفحات ۴۲۶-۴۳۴

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023